• 2.3.1 Primary Hallmarks – Causes of Damage: Focus on the initial causes of cellular damage such as genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and disabled macroautophagy.
• 2.3.2 Antagonistic Hallmarks – Responses to Damage: Analyze the responses to damage that initially mitigate damage but eventually become detrimental, including deregulated nutrient-sensing, mitochondrial dysfunction and cellular senescence. .
• 2.3.3 Integrative Hallmarks – Culprits of the Phenotype: Discuss factors of stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. that directly impact the aging phenotype.
  
  

• Coaching Corner: Triage Thinking – Develop a strategic approach to assess and prioritize interventions based on the severity and impact of aging signs in clients.
• Business Builder: Mapping the Client Journey to Age Optimization – Learn to create effective, personalized client journeys that address specific aging concerns, enhancing client engagement and outcomes.

• 3.2.1 Methylation: Explore how DNA methylation affects gene expression and the aging process.
• 3.2.2 Acetylation and Histone Modification: Examine the role of histone acetylation in chromatin structure and gene expression.
  

• Coaching Corner: Communication for Connection and Change – Enhance skills in effective communication to foster deep connections with clients and facilitate meaningful change.
• Business Builder: Finding Your Ideal Clients – Strategies to identify and attract clients who can most benefit from epigenetic interventions for longevity.
  

• Business Builder: Attracting Your Ideal Client – Develop targeted strategies to identify and attract clients who can most benefit from stress management interventions.
• Coaching Corner: The Science of Questioning – Enhance coaching skills with effective questioning techniques that help clients uncover stressors and develop coping strategies.
  

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• Business Builder: What Clients Want – Learn to identify and fulfill the specific needs and desires of clients seeking longevity through metabolic optimization.
• Coaching Corner: 4 Steps for Enhanced Self-Awareness – A practical guide to developing self-awareness in clients, crucial for effective metabolic management and lifestyle adjustments.

• Business Builder: 5 Minute Content Creation Strategy: Quick and efficient strategies for creating impactful content that enhances client engagement and promotes the longevity practice.
• Slide Deck: A comprehensive slide deck summarizing key points from the lesson, designed to aid in learning retention and as a quick reference tool.
• Practical Exam 1: The Consultation Challenge: Students will perform a simulated consultation based on the frameworks discussed, demonstrating their ability to apply theoretical knowledge in practical settings.
  

• Interactive Lab Session: Engage in a hands-on lab session where students will interpret various sets of biomarker data to make clinical decisions.
• Technology Integration: Introduction to software and applications that can aid in tracking digital biomarkers and integrating them into patient care plans.

• Examine the core components necessary to maintain and enhance cognitive health and overall mental vitality.
  

• Discuss how mindset, perceptions, and beliefs directly influence mental health and cognitive resilience.

• Explore the relationship between brainwaves, neurotransmitters, and the physical structure of the brain in cognitive function.
  

• Analyze how the brain evolves and changes through different life stages and the implications for cognitive function.

• Investigate the critical roles of oxygen supply, energy production, and blood circulation in supporting brain health.
  

• Explore how external factors like light, sound, and temperature affect brain health and cognitive function.

• Discuss the use of nootropics, nutrient-sensing molecules, and peptides in enhancing cognitive functions and brain health.
  

• Review cognitive and physical exercises that promote brain coherence, improve memory, and enhance mental performance.

• Consider how technology can be leveraged to enhance cognitive functions and potentially increase business revenue through innovative solutions.
  

• Explore how regular physical movement contributes to longevity and the mechanisms behind its health benefits.
  

• Discuss the typical changes in mobility that occur with aging and strategies to mitigate these effects through targeted exercises.
  

• Examine how breathing techniques can enhance lung capacity, oxygen saturation, and overall respiratory health.

• NEAT
• ZONE 2 & 3
• HIIT
• Resistance
• Importance of VO2 

• Analyze the impact of various forms of exercise on epigenetic markers and how they influence longevity, focusing on developing strength, speed, balance, and flexibility.

• Outline age-appropriate fitness regimens that optimize health and functional ability throughout different life stages.
  

• How to Assess fitness biomarkers, grip strength, sit-to-stand, step test for HR, intensity and recovery, mobility, balance, strength, and functional movement patterns to build progressive programs that improve longevity outcomes.

• Develop comprehensive fitness programs that integrate various aspects of fitness training tailored to individual needs and goals for long-term health.

• Provide strategies for identifying and collaborating with fitness partners and resources that can support clients in achieving their fitness and longevity goals.

• Introduce principles of a longevity-supporting diet, focusing on foods known to enhance lifespan and prevent age-related diseases.

• Cover the fundamentals of human digestion and how it influences nutrient absorption and overall health.

• Explore the role of epinutrients in genetic expression and the environmental factors that influence methylation processes in the body.
  

• Discuss the balance of macronutrients, the role of mTOR in metabolism and aging, and how dietary choices impact metabolic health.
  

• Explain the concepts of senolytics and autophagy, their importance in cellular health, and their impact on the immune system.
  

• Detail the function of sirtuins in DNA repair and maintenance and their significance in cellular health and longevity.

• Examine the effects of fasting and calorie restriction on health and longevity, including their impact on the body’s circadian rhythms.
  

• Analyze the role of bioactive compounds and sort foods in promoting longevity and how to incorporate these into a daily diet.
  

• Discuss approaches to personalize nutrition plans based on individual client needs, preferences, and specific health goals.
  

• Introduce the concept of rest as a foundational element for resilience and longevity, including the physiological benefits of adequate rest.
  

• Explore different types of rest, focusing on sleep as a critical component of recovery and its various stages and types.
  

• Define allostasis and allostatic overload, explaining how chronic stress impacts physiological systems and the importance of managing these for resilience.

• Discuss how sleep supports resilience by restoring physical and mental health, and delve into the mechanics of how sleep contributes to recovery.

• Present practical interventions and strategies to optimize rest, recovery, and resilience, including techniques like meditation, napping, and relaxation exercises.

• Analyze how environmental design influences resilience, covering aspects of light, noise, and room layout that promote restful and restorative environments.
  

• Extend the discussion to broader environmental factors, including air quality and temperature control, to enhance resilience through optimal living and working conditions.

• Examine circadian rhythms and their influence on recovery processes, discussing how aligning lifestyle with natural biological clocks can boost resilience and overall well-being.

• Explore the concept of wellbeing and its critical role in enhancing lifespan and healthspan, examining how psychological, social, and physical wellbeing contribute to longevity.

• Analyze the lifestyles, diets, and community structures of the world’s Blue Zones where people live the longest, extracting practical lessons that can be applied universally.
  

• Introduce tools and techniques for assessing personal well-being and strategies for optimization, focusing on individual health, lifestyle, and environmental factors.
  

• Define biohacking and explore its goals of manipulating biological processes through science, technology, and self-experimentation.
  

• Examine natural biohacking approaches that leverage light, sound, temperature, and oxygen to enhance health based on evolutionary principles.
  

• Discuss the critical role of natural sunlight in regulating circadian rhythms, improving sleep, and enhancing metabolic health.
  

• Explore how sound frequencies and rhythms can influence brain function, mood, and cognitive capabilities.
  

• Analyze the health benefits of exposure to various temperatures, focusing on metabolic and immune system enhancements. 

• Describe techniques to improve oxygen intake and utilization for better cellular metabolism and overall physiological function. Learn how to use various forms of breathwork to improve clinical outcomes and slow the pace of aging.

• Delve into advanced biohacking technologies that complement and enhance natural methods, including photobiomodulation and thermal regulation.

• Explain how PBM uses specific light wavelengths to improve cell function, particularly for reducing inflammation and enhancing recovery.
  
  

• Discuss structured sound wave applications for manipulating brain activity and achieving desired mental states.

• Cover the use of modern tools like saunas and cryotherapy chambers for controlled temperature exposure and its health benefits.
  

• Explore high-altitude and hyperbaric oxygen therapies to increase oxygen density and improve systemic health.
  

• Provide practical coaching strategies to help clients safely integrate biohacking techniques into their lifestyle for optimal health benefits.
  

• Introduce the concept of advanced therapies in longevity medicine, discussing their potential to enhance healthspan and quality of life.

• Explore the role of hormone replacement therapy in managing age-related decline, detailing its benefits, risks, and potential effects on longevity.

• Discuss the use of peptide therapy in longevity medicine, focusing on how peptides can regulate biological functions to improve health outcomes.

• Examine intravenous therapies used to deliver nutrients and therapeutic agents directly into the bloodstream for improved bioavailability and therapeutic impact.

• Analyze the use of ozone therapy, senolytics for senescent cell clearance, and stem cell therapies as tools for promoting regeneration and recovery.
  

• Cover a range of regenerative therapies including tissue engineering, regenerative medicine, and other interventions aimed at repairing and rejuvenating the body.
  

• Bonus 1: Peptides for Immune Support with Dr. Kent Holtorf
  • Special session with Dr. Holtorf discussing the specific uses of peptides in boosting the immune system and their relevance in longevity medicine.
• Bonus 2: Molecules of Longevity with Dr. Pastrana
  • A deep dive with Dr. Pastrana into the molecular mechanisms that underpin aging and longevity, focusing on emerging molecules of interest in the field.
    

• Explore the fundamentals of impactful communication, emphasizing clarity, empathy, and connection.
  

• Discuss the principle that communication is 7% verbal, 38% tone of voice, and 55% body language, and its implications for coaching.
  

• Examine techniques for building rapport with clients to foster trust and openness.
  

• Highlight the importance of active listening in understanding client needs and fostering effective dialogue.
  

• Explore how linguistic patterns and strategic questioning can uncover deeper insights and motivate clients.

• Discuss the technique of matching and mirroring client behaviors to enhance communication and connection.
  
  

• Explain how to pace and lead conversations to guide clients gently through their change process.

• Cover strategies to initiate and sustain change, emphasizing motivational interviewing and change management theories.
  

• Delve into the psychological stages of change and how to support clients through each phase effectively.

• Investigate how coaching interventions can affect the brain and nervous system, influencing behavior and cognitive functions.
  

• Introduce interventions from positive psychology that enhance well-being and support longevity practices.
  
  

• Describe the process of habit stacking to build new, healthy behaviors by linking them to existing habits.

• Explore techniques for helping clients shift their mindsets and identities to support lasting change.
  

• Discuss the role of the coach in guiding the client through the complexity of lifestyle change for longevity.

• Introduce the Acceptance and Commitment Therapy (ACT) framework as applied in coaching to promote psychological flexibility.
  

• Techniques to keep clients engaged and motivated throughout the coaching process.

• Outline the importance and methods of conducting a previsit check-in to set the stage for effective coaching sessions.
  

• Detail the structure and flow of an actual coaching visit, focusing on maximizing impact and efficiency.

• Strategies to facilitate deep, transformational changes in clients, ensuring lasting impacts on their health and longevity.
  

• Teach the technique of breaking complex issues into manageable parts to achieve agreement and encourage action.
  
  

• Offer strategies for turning effective coaching conversations into client relationships and business opportunities.

• Explore three successful business models in the longevity industry and how they can be adapted to different business goals.

• Learn to define and understand the ideal client profile to effectively target and meet their specific needs.

• Develop a structured approach to creating programs that deliver tangible health benefits and align with business objectives.

• Discuss how to set up pricing and structural strategies that balance profitability with client accessibility.

• Analyze current trends in the longevity market and identify emerging opportunities.
  

• Implement strategies for quickly launching and scaling your longevity business.
  
  

• Outline a client journey map from initial contact through to becoming a paying client, including engagement strategies and conversion tactics.
  

• Learn how to effectively map out program offerings, focusing on the timing, type, and frequency of client interactions.
  

• Explore essential systems and platforms that support business operations, from client management to program delivery.
  

• Discuss the importance and implementation of Electronic Health Records and Electronic Medical Records systems in managing client data.
  

• Examine the role of biometric tracking technologies in monitoring and enhancing client health outcomes.
  

• Develop strategies for creating and distributing educational and promotional content that engages and retains clients.

• Review legal issues including compliance with healthcare regulations and data protection laws.

• Define and understand the legal and ethical boundaries of practice within the longevity industry.
  
  

• Cover ethical considerations essential to maintaining professionalism and trust in a longevity practice.

• Analyze various case studies across lifestyle, clinical, marketing, and product domains to extract lessons and best practices.